Fluoride nanocrystals and quantum dots nanocomposite for efficient luminescence nanothermometer in NIR-II biological window

• Published in: Journal of alloys and compounds Vol. 989; p. 174336
• Main Authors: Du, Zhengying, Li, Denghao, Lei, Lei, Bai, Gongxun, Wang, Huanping, Zhang, Xianghua, Xu, Shiqing, Qiu, Jianrong
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 25.06.2024; Elsevier
• Subjects: Ag2S quantum dots; Biological; Chemical Sciences; Material chemistry; Nanocomposite; Nanocrystals; Nanothermometer; NIR-II; NIR-II; Nanocomposite; Nanocrystals; Biological; Ag2S quantum dots; Nanothermometer
• ISSN: 0925-8388; 1873-4669
• DOI: 10.1016/j.jallcom.2024.174336

Biosensors working in the second near-infrared (NIR-II) spectral region have recently gained great attention owning to their deep tissue bioimaging and high spatiotemporal resolution. However, there is still a challenge to develop efficient nanothermometers based on NIR-II luminescence. Herein, we present a pioneering advancement in the field of nanothermometry by synthesizing a novel nanothermometer, a composite of fluoride nanocrystals and quantum dots. This NaYF4:1Nd-Ag2S QDs@SiO2 nanocomposite demonstrates exceptional functionality, being excited by a single light irradiation at 808 nm for NIR-II luminescence imaging. Notably, the composite emits at two distinct wavelengths-1064 nm and 1125 nm, attributable to Nd3+ and Ag2S QDs, respectively. This unique emission profile enables deeper tissue penetration, mitigating overheating risks compared to conventional excitation sources at 980 nm. Furthermore, the nanomaterials exhibit remarkable temperature-sensing capabilities, with maximum sensitivities of 0.81%K−1 (SR) at 333 K. These superior sensitivities outperform many existing temperature sensors relying on thermally coupled Stark sublevels. The SiO2 matrix not only encapsulates and protects the fluoride nanocrystals and quantum dots but also shields them from aqueous environments, ensuring outstanding luminescence stability. Our findings highlight the potential of this nanothermometer as a highly efficient temperature sensor with promising applications in cutting-edge bioapplications. This development introduces a new frontier in temperature sensing and bioimaging, showcasing its potential for transformative contributions to the field. [Display omitted] •Successful synthesis of a novel nanothermometer based on a composite comprising fluoride nanocrystals and quantum dots.•The emission intensity of Nd3+ and Ag2S QDs serves as a temperature sensing mechanism (0.81%K−1 (SR) at 333 K).•A versatile platform allows the integration of two different luminescent nanomaterials to meet customized requirements.•The SiO2 matrix shields NCs and Ag2S QDs from water environments, ensuring excellent luminescence stability.