Altered Sequence of Pubertal Changes and Accelerated Bone Maturation in A 10-Year-Old Japanese Boy with Nonendocrine Short Stature Treated with GH

A 10-year-old Japanese boy with nonendocrine short stature who was treated with GH showed discordant pubertal development and advanced skeletal maturation. GH therapy was started at 6.8 years of age at a dose of 0.5u/kg/week, when his height age was 3.3 years and bone age was 4.8 years. At 10.3 year...

Full description

Saved in:
Bibliographic Details
Published inClinical Pediatric Endocrinology Vol. 3; no. Supple4; pp. 125 - 127
Main Authors Sato, Seiji, Anzo, Makoto, Kamimaki, Tsutomu, Fukami, Maki, Matsuo, Nobutake
Format Journal Article
LanguageEnglish
Published The Japanese Society for Pediatric Endocrinology 1994
Subjects
abnormal pubertal development
accelerated bone maturation
GH therapy
Leydig cell activation
nonendocrine short stature
Online AccessGet full text

Cover

More Information
Summary:A 10-year-old Japanese boy with nonendocrine short stature who was treated with GH showed discordant pubertal development and advanced skeletal maturation. GH therapy was started at 6.8 years of age at a dose of 0.5u/kg/week, when his height age was 3.3 years and bone age was 4.8 years. At 10.3 years of age his height and bone age reached 7.5 and 9.0 years, respectively, but unexpectedly he developed pubic hair (Tanner stage II, with a testicular volume of 4mL). It appears that the pharmacological dose of GH prematurely induced Leydig cell activity in this patient.
ISSN:0918-5739
1347-7358
DOI:10.1297/cpe.3.Supple4_125