Analysis of HLA-A, C, B, DR and DQ loci in an Italian sample of possible Celtic origin

• Published in: Tissue antigens Vol. 45; no. 5; p. 295
• Main Authors: Matullo, G, Griffo, R M, Mangione, A M, Cappello, N, Rendine, S, Piazza, A
• Format: Journal Article
• Language: English
• Published: England 01.05.1995
• Subjects: Alleles; Emigration and Immigration; Female; Gene Frequency; Haplotypes; Heterozygote; HLA Antigens - genetics; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-C Antigens - genetics; HLA-DQ Antigens - genetics; HLA-DR Antigens - genetics; Humans; Italy; Linkage Disequilibrium; Male; Prospective Studies; Italy
• ISSN: 0001-2815
• DOI: 10.1111/j.1399-0039.1995.tb02457.x

Trino Vercellese, a village of Piedmont (Italy), was selected with the aim at reconstructing the genetic history of a putative Celtic sample known to be settled in Italy with the name of Rigomagus since pre-roman times. The HLA-A, Cw, B, DR and DQ antigens of 101 unrelated individuals have been typed. The antigens characterizing this sample for their higher frequency are shown to be A3, A11, A32, B35, B39, Bw52, Cw4, DRw11, DRw13, DQw7. Gene frequencies are estimated by maximum likelihood and Hardy-Weinberg equilibrium was tested with no deviant genetic locus. Two-locus haplotype frequencies were also estimated and those with significant associations tabulated. "Extended" haplotypes were reconstructed: the three most frequent haplotypes (covering a total frequency of 11.5%) share the same Cw, B, DR and DQ alleles. Comparisons with other Italian and European samples are indicated to challenge archeological evidence of a pre-roman genetic stratification of the people living in our old Rigomagus.