LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR‐377‐3p

Up to date, the mechanism of gastric cancer (GC) development is poorly understood. This study was to demonstrate the effects of LINC00339 on GC progression. Here, we found that LINC00339 was overexpressed expressed in GC tissues and predicted poor outcome. By CCK8, colony formation and Transwell ass...

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Published inJournal of cellular physiology Vol. 234; no. 12; pp. 23667 - 23674
Main Authors Shi, Chengmin, Liu, Tonglei, Chi, Junlin, Luo, Huayou, Wu, Zhizhong, Xiong, Binghong, Liu, Shuang, Zeng, Yujian
Format Journal Article
LanguageEnglish
Published United States 01.12.2019
Subjects
Apoptosis - genetics
Cell Line, Tumor
Cell Movement - genetics
Cell Proliferation - genetics
DCP1A
Disease Progression
Endoribonucleases - biosynthesis
gastric cancer
Humans
LINC00339
MicroRNAs - genetics
miR‐377‐3p
Neoplasm Invasiveness - genetics
Neoplasm Transplantation
Oncogenes - genetics
progression
RNA Interference
RNA, Long Noncoding - genetics
RNA, Small Interfering - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
Trans-Activators - biosynthesis
Transplantation, Heterologous
miR-377-3p
progression
LINC00339
gastric cancer
DCP1A
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Summary:Up to date, the mechanism of gastric cancer (GC) development is poorly understood. This study was to demonstrate the effects of LINC00339 on GC progression. Here, we found that LINC00339 was overexpressed expressed in GC tissues and predicted poor outcome. By CCK8, colony formation and Transwell assays, we showed LINC00339 knockdown suppressed GC cell proliferation, migration, and invasion in vitro. Flow cytometry analysis (FACS) indicated that LINC00339 knockdown induced tumor cell apoptosis. Besides, we utilized the xenograft assay and found that LINC00339 depletion led to decreased tumor growth in vivo. Mechanistically, miR‐377‐3p was found to be inhibited by LINC00339. And LINC00339 suppressed miR‐377‐3p to upregulate DCP1A, which consequently promoted GC progression. In conclusion, LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR‐377‐3p. LINC00339 promotes gastric cancer progression by elevating DCP1A expression via inhibiting miR‐377‐3p.
Bibliography:Chengmin Shi, Tonglei Liu, and Junlin Chi contributed equally to this study.
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ISSN:0021-9541
1097-4652
1097-4652
DOI:10.1002/jcp.28934