Biofactors regulating mitochondrial function and dynamics in podocytes and podocytopathies

• Published in: Journal of cellular physiology Vol. 238; no. 10; pp. 2206 - 2227
• Main Authors: Hejazian, Seyyedeh Mina, Ardalan, Mohammadreza, Hosseiniyan Khatibi, Seyed Mahdi, Rahbar Saadat, Yalda, Barzegari, Abolfazl, Gueguen, Virginie, Meddahi‐Pellé, Anne, Anagnostou, Fani, Zununi Vahed, Sepideh, Pavon‐Djavid, Graciela
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc 01.10.2023
• Subjects: Bioenergetics; Cell differentiation; Damage; Diabetic nephropathy; Environmental risk; Homeostasis; Kidney diseases; Kidneys; Mitochondria; Proteinuria; Risk factors; Therapeutic targets
• ISSN: 0021-9541; 1097-4652
• DOI: 10.1002/jcp.31110

Abstract Podocytes are terminally differentiated kidney cells acting as the main gatekeepers of the glomerular filtration barrier; hence, inhibiting proteinuria. Podocytopathies are classified as kidney diseases caused by podocyte damage. Different genetic and environmental risk factors can cause podocyte damage and death. Recent evidence shows that mitochondrial dysfunction also contributes to podocyte damage. Understanding alterations in mitochondrial metabolism and function in podocytopathies and whether altered mitochondrial homeostasis/dynamics is a cause or effect of podocyte damage are issues that need in‐depth studies. This review highlights the roles of mitochondria and their bioenergetics in podocytes. Then, factors/signalings that regulate mitochondria in podocytes are discussed. After that, the role of mitochondrial dysfunction is reviewed in podocyte injury and the development of different podocytopathies. Finally, the mitochondrial therapeutic targets are considered.