A whole genome scan reveals distinct features of selection in Zhaotong cattle of Yunnan province
Abstract Over the years, indigenous cattle have not only played an essential role in securing primary food sources but have also been utilized for labor by humans, making them invaluable genetic resources. The Zhaotong cattle, a native Chinese breed from the Yunnan province, possess excellent meat q...
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Published in | Animal genetics Vol. 54; no. 6; pp. 731 - 742 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Wiley Subscription Services, Inc
01.12.2023
|
Subjects | |
Online Access | Get full text |
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Summary: | Abstract
Over the years, indigenous cattle have not only played an essential role in securing primary food sources but have also been utilized for labor by humans, making them invaluable genetic resources. The Zhaotong cattle, a native Chinese breed from the Yunnan province, possess excellent meat quality and resistance to heat and humidity. Here we used whole genome sequencing data of 104 animals to delve into the population structure, genomic diversity and potential positive selection signals in Zhaotong cattle. The findings of this study demonstrate that the genetic composition of Zhaotong cattle was primarily derived from Chinese indicine cattle and East Asian cattle. The nucleotide diversity of Zhaotong cattle was only lower than that of Chinese indicine cattle, which was much higher than that of other taurine cattle. Genome‐wide selection scans detected a series of positive candidate regions containing multiple key genes related to bone development and metabolism (
CA10
,
GABRG3
,
GLDN
and
NOTUM
), meat quality traits (
ALG8
,
LINGO2
,
MYO5B
,
PRKG1
and
GABRB
1), immune response (
ADA2
,
BMF
,
LEF1
and
PAK6
) and heat resistance (
EIF2AK4
and
LEF1
). In summary, this study supplies essential genetic insights into the genome diversity within Zhaotong cattle and provides a foundational framework for comprehending the genetic basis of indigenous cattle breeds. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0268-9146 1365-2052 |
DOI: | 10.1111/age.13363 |