Mild Cognitive Impairment Subtypes in Older People With Depressive Symptoms: Relationship With Clinical Variables and Hippocampal Change

To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms and to determine the relative contribution of hippocampal volume and MCI to memory change. One hundred and fifty-two participants with lifetime Major Depression and remitted...

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Published inJournal of geriatric psychiatry and neurology Vol. 28; no. 3; p. 174
Main Authors Jayaweera, Hirosha K, Hickie, Ian B, Duffy, Shantel L, Hermens, Daniel F, Mowszowski, Loren, Diamond, Keri, Terpening, Zoe, Paradise, Matthew, Lewis, Simon J G, Lagopoulos, Jim, Naismith, Sharon L
Format Journal Article
LanguageEnglish
Published United States 01.09.2015
Subjects
Adult
Age Factors
Aged
Atrophy - pathology
Cognitive Dysfunction - classification
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - psychology
Depression - psychology
Depressive Disorder, Major
Female
Hippocampus - pathology
Humans
Magnetic Resonance Imaging - methods
Male
Memory
Middle Aged
Neuroimaging
Neuropsychological Tests - statistics & numerical data
Psychiatric Status Rating Scales
Risk Factors
Neuroimaging
Depression
Mild Cognitive Impairment
MRI
Memory
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Summary:To examine the rates and clinical characteristics of mild cognitive impairment (MCI) in older people with depressive symptoms and to determine the relative contribution of hippocampal volume and MCI to memory change. One hundred and fifty-two participants with lifetime Major Depression and remitted or mild symptoms and 28 healthy controls underwent psychiatric and neuropsychological assessments. Magnetic resonance imaging was also conducted in a subset of the patients (n = 81) and healthy controls (n = 18). MCI was diagnosed in 75.7% of the patients and was associated with increasing age, medical burden, vascular risk factors, later age of depression onset and smaller hippocampi. Multiple regression showed that both hippocampal volume and MCI diagnosis mediate memory performance in depression. MCI occurs in older adults with a history of depression and is not simply due to symptom severity. Memory change is linked to underlying hippocampal atrophy in this patient group.
ISSN:0891-9887
DOI:10.1177/0891988715573535