Evidence for gamma-MSH-like immunoreactivity in ectopic ACTH-producing tumors

Using a specific radioimmunoassay for gamma-MSH, a predicted peptide in the cryptic N-terminal portion of the adrenocorticotropin-beta-lipotropin precursor, gamma-MSH-like immunoreactivity (gamma-MLI) was detected in two ectopic ACTH producing tumors. Gel chromatographic studies on Bio-Gel P-60 reve...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 50; no. 6; p. 1147
Main Authors Nakai, Y, Tanaka, I, Fukata, J, Nakao, K, Oki, S, Takai, S, Imura, H
Format Journal Article
LanguageEnglish
Published United States 01.06.1980
Subjects
Adrenocorticotropic Hormone - analysis
Adrenocorticotropic Hormone - secretion
beta-Lipotropin - analysis
Endorphins - analysis
Humans
Melanocyte-Stimulating Hormones - analysis
Radioimmunoassay
Thyroid Neoplasms - analysis
Thyroid Neoplasms - secretion
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Summary:Using a specific radioimmunoassay for gamma-MSH, a predicted peptide in the cryptic N-terminal portion of the adrenocorticotropin-beta-lipotropin precursor, gamma-MSH-like immunoreactivity (gamma-MLI) was detected in two ectopic ACTH producing tumors. Gel chromatographic studies on Bio-Gel P-60 revealed one or two peaks of gamma-MLI; one was eluted near th elution position of beta-LPH, compatible with gamma-MLI in human pituitary and the other emerged near the position of beta-endorphin. These results indicate that ectopic ACTH-producing tumors eleborate not only ACTH, beta-endorphin but also gamma-MLI.
ISSN:0021-972X
DOI:10.1210/jcem-50-6-1147