Plasma concentration and uterine and ovarian expressions of insulin-like growth factor-2 in dogs with cystic endometrial hyperplasia-pyometra

The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)-pyometra complex. Group 1 (n = 10) included bitches with open cervix...

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Published inActa veterinaria Hungarica (Budapest. 1983) Vol. 69; no. 1; p. 73
Main Authors Gültiken, Nilgün, Yarim, Murat, Yarim, Gül Fatma, Sözmen, Mahmut, Anadol, Elvan, Findik, Murat
Format Journal Article
LanguageEnglish
Published Hungary 22.04.2021
Subjects
Animals
Dog Diseases
Dogs
Endometrial Hyperplasia - veterinary
Female
Insulin-Like Growth Factor II
Ovary
Pyometra - veterinary
insulin-like growth factor-2
ovary
uterus
dog
cystic endometrial hyperplasia–pyometra
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Summary:The objective of this study was to investigate the plasma concentrations of insulin-like growth factor-2 (IGF-2) as well as its expression in the uterus and ovary of healthy dogs and those with cystic endometrial hyperplasia (CEH)-pyometra complex. Group 1 (n = 10) included bitches with open cervix pyometra, while Group 2 (n = 7) consisted of clinically healthy bitches in dioestrus. The number of IGF-2 immunopositive interstitial cells was significantly higher in Group 1, whereas in Group 2 there were only two cases in which a few cells were IGF-2 immunopositive. IGF-2 immunopositivity was observed in the endometrial glandular epithelium in both groups. Additionally, interstitial fibroblasts and macrophages in the endometrium were also positive in Group 1. The concentration of plasma IGF-2 was higher in Group 1 than in Group 2 (P < 0.05). The concentration was positively correlated with IGF-2 expression in the endometrial glands (r = 0.926; P < 0.001) in Group 1. However, a negative correlation was present between plasma IGF-2 concentration and IGF-2 expression in the interstitial endocrine cells of the ovary in Group 1 (r = -0.652; P < 0.05). The results suggest that IGF-2 plays an important role during the inflammatory process occurring in bitches with CEH-pyometra complex as well as in the endometrium of healthy bitches in dioestrus.
ISSN:0236-6290
DOI:10.1556/004.2021.00013