N terminal-pro brain natriuretic peptide in fetal umbilical cord meconium-stained amniotic fluid: a prospective case control study

To evaluate the value of N terminal-pro brain natriuretic peptide (NTpBNP) levels in fetuses with meconiumtained amniotic fluid (MSAF). In this case control study, of 36 fetuses, 19 had MSAF and 17 had normal, as controls. The blood samples were taken from the fetal umbilical cord just after birth t...

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Published inClinical and experimental obstetrics & gynecology Vol. 43; no. 3; p. 370
Main Authors Kaba, M, Engin-Ustun, Y, Kaba, G, Eyil, E G Yapar, Uysal, S, Mollamahmutoglu, L
Format Journal Article
LanguageEnglish
Published Canada 01.01.2016
Subjects
Adult
Amniotic Fluid
Biomarkers - blood
Case-Control Studies
Female
Fetal Blood - metabolism
Humans
Infant, Newborn
Male
Meconium
Natriuretic Peptide, Brain - metabolism
Peptide Fragments - metabolism
Pregnancy
Prospective Studies
Young Adult
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Summary:To evaluate the value of N terminal-pro brain natriuretic peptide (NTpBNP) levels in fetuses with meconiumtained amniotic fluid (MSAF). In this case control study, of 36 fetuses, 19 had MSAF and 17 had normal, as controls. The blood samples were taken from the fetal umbilical cord just after birth to measure NTpBNP levels. Mean NTpBNP values were 1.01 ± 0.49 ng/ml in the patient group and 1.70 ± 0.93 ng/ml in the control group. The difference between the groups was statistically significant (p = 0.01) and power was 78% at 95% confidence interval. Serum NTpBNP levels were decreased in the study group. The result suggests that NTpBNP may be a valuable marker for fetuses with MSAF.
ISSN:0390-6663
DOI:10.12891/ceog3124.2016