Anti-skin-aging effects of human ceramides via collagen and fibrillin expression in dermal fibroblasts

ABSTRACT Intercellular lipids comprise mainly ceramides, known to enhance the barrier function of the stratum corneum. However, the activities of ceramides inside the skin have not yet been fully elucidated. Here we examined how the human ceramide mixture (HC123) functions in the dermis. We treated...

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Published inBioscience, biotechnology, and biochemistry Vol. 86; no. 9; pp. 1240 - 1246
Main Authors Sugahara, Yurika, Komorisono, Masahiko, Kuwajima, Mami, Yoshikawa, Shuichi, Yoshida, Shiori, Maeda, Kazuhisa
Format Journal Article
LanguageEnglish
Published 24.08.2022
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Summary:ABSTRACT Intercellular lipids comprise mainly ceramides, known to enhance the barrier function of the stratum corneum. However, the activities of ceramides inside the skin have not yet been fully elucidated. Here we examined how the human ceramide mixture (HC123) functions in the dermis. We treated human skin fibroblasts with HC123-expressed fibroblast growth factor (FGF), transforming growth factor-β (TGF-β), collagen I, and fibrillin. We found that HC123 promoted the formation of collagen fibers and microfibrils (fibrillin) which affect the elasticity of the skin. We also confirmed that the gene expression of collagen and fibrillin is promoted via TGF-β and FGF2, respectively. We then investigated the permeability of HC123 for external use, in pursuit of evidence that HC123 may exert an anti-aging effect by penetrating into the dermis, activating fibroblasts, and promoting the production of collagen fibers and elastin-related microfibrils.
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ISSN:1347-6947
1347-6947
DOI:10.1093/bbb/zbac107