Modified substrates of DNA polymerases and design of antivirals

The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.

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Bibliographic Details
Published inActa biochimica polonica Vol. 43; no. 1; pp. 125 - 132
Main Authors Krayevsky, A A, Alexandrova, L A, Dyatkina, N B, Kukhanova, M K, Shirokova, E A
Format Journal Article
LanguageEnglish
Published Poland 01.01.1996
Subjects
AIDS/HIV
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Deoxyribonucleotides - chemical synthesis
Deoxyribonucleotides - chemistry
Deoxyribonucleotides - pharmacology
DNA-Directed DNA Polymerase - metabolism
Drug Design
HIV - drug effects
HIV - physiology
Humans
Nucleic Acid Synthesis Inhibitors
Retroviridae - drug effects
Reverse Transcriptase Inhibitors - chemical synthesis
Reverse Transcriptase Inhibitors - pharmacology
Simplexvirus - drug effects
Virus Replication - drug effects
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Summary:The results obtained in our laboratory on investigating of substrate properties of a large number of compounds towards different DNA polymerases have been summarized. On the basis of systematic analysis a directed synthesis of nucleotides with antiviral properties was performed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0001-527X
1734-154X
DOI:10.18388/abp.1996_4523