The induction of tolerance by cyclosporine-G in experimental autoimmune uveitis in the Lewis rat

Cyclosporine-G inhibits retinal S-antigen-induced experimental autoimmune uveitis in a manner similar to Cyclosporine-A (CsA). In sufficiently high doses it induces a state of tolerance in the animal which persists after cessation of therapy.

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Bibliographic Details
Published inJournal of ocular pharmacology Vol. 3; no. 2; p. 135
Main Authors Dinning, W J, Nussenblatt, R B, Kuwabara, T, Leake, W
Format Journal Article
LanguageEnglish
Published United States 1987
Subjects
Animals
Antigens - immunology
Arrestin
Autoimmune Diseases - immunology
Autoimmune Diseases - pathology
Cell Division
Cyclosporine
Cyclosporins - pharmacology
Eye Proteins - immunology
Female
Immune System - drug effects
Immune Tolerance
Lymph Nodes - pathology
Rats
Rats, Inbred Lew
Uveitis - immunology
Uveitis - pathology
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Summary:Cyclosporine-G inhibits retinal S-antigen-induced experimental autoimmune uveitis in a manner similar to Cyclosporine-A (CsA). In sufficiently high doses it induces a state of tolerance in the animal which persists after cessation of therapy.
ISSN:8756-3320
DOI:10.1089/jop.1987.3.135