Therapeutic experience of severe and recurrent secondary hyperparathyroidism in a patient on hemodialysis for 18 years: A case report

• Published in: Medicine (Baltimore) Vol. 97; no. 20; p. e10816
• Main Authors: Zhu, Mingwen, Zhang, Zongming, Lin, Fangcai, Miao, Jieping, Wang, Pei, Zhang, Chong, Yu, Hongwei, Deng, Hai, Liu, Zhuo, Liu, Limin, Wan, Baijiang, Yang, Haiyan, Song, Mengmeng, Zhao, Yue, Jiang, Nan, Zhang, Zichao, Zhang, Zhenya, Pan, Lijie
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health 01.05.2018
• Subjects: Clinical Case Report; Female; Humans; Hyperparathyroidism, Secondary - surgery; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - therapy; Middle Aged; Parathyroid Glands - transplantation; Parathyroidectomy - methods; Recurrence; Renal Dialysis - adverse effects; Retrospective Studies; Time Factors; Transplantation, Autologous
• ISSN: 0025-7974; 1536-5964
• DOI: 10.1097/MD.0000000000010816

For patients with refractory secondary hyperparathyroidism (SHPT), parathyroidectomy (PTX) has received increasing attention. However, evidence-based medicine shows that there is still controversy regarding surgical methods, efficacy, and safety. We retrospectively analyzed the process of diagnosis and treatment in one patient with severe SHPT and long-term chronic renal failure (CRF), so as to further improve the therapeutic effect. A 61-year-old female with SHPT and CRF manifested as no urine for 18 years, underwent PTX 4 times since September 2010, with satisfactory final recovery. The first operation involved resection of 3 parathyroid glands in the normal position; the second operation involved removal of an ectopic parathyroid gland, combined with parathyroid gland autotransplantation; the third operation was performed to resect suspected recurrent parathyroid gland; the fourth operation involved partial excision of the autotransplanted parathyroid glands. Accurate preoperative localized diagnosis and optimal surgical approach play key roles in the prevention and treatment of SHPT; postoperative recurrence of SHPT caused by ectopic or autotransplanted parathyroid gland should receive more attention.