Microarray technology: an increasing variety of screening tools for proteomic research

Protein microarray technology allows the simultaneous determination of a large variety of parameters from a minute amount of sample within a single experiment. Assay systems based on this technology are currently used for the identification, quantitation and functional analysis of proteins that are...

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Bibliographic Details
Published inDrug Discovery Today: Targets Vol. 3; no. 1; pp. 24 - 31
Main Authors Stoll, Dieter, Bachmann, Jutta, Templin, Markus F., Joos, Thomas O.
Format Book Review Journal Article
LanguageEnglish
Published Elsevier B.V 01.02.2004
Subjects
antibody array
biochip
cell array
microarray
protein array
SELDI
SELEX
tissue array
tissue array
microarray
protein array
cell array
antibody array
SELDI
biochip
SELEX
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Summary:Protein microarray technology allows the simultaneous determination of a large variety of parameters from a minute amount of sample within a single experiment. Assay systems based on this technology are currently used for the identification, quantitation and functional analysis of proteins that are of interest for proteomic research in basic and applied biology and for diagnostic applications. Such novel assays are also of major interest for the pharmaceutical industry, focusing on the identification of biomarkers and the validation of potential target molecules. Sensitivity, reproducibility, robustness and automation have to be demonstrated before this technology will be suitable for high-throughput applications.
ISSN:1741-8372
1878-7363
DOI:10.1016/S1741-8372(04)02400-4