Long-Term Mortality Rates in Acute De Novo Versus Acute-on-Chronic Heart Failure: From the Heart Function Assessment Registry Trial in Saudi Arabia

• Published in: Angiology Vol. 66; no. 9; p. 837
• Main Authors: AlHabib, Khalid F, Kashour, Tarek, Elasfar, Abdelfatah A, Alfaleh, Hussam, Hersi, Ahmad, Alshamiri, Mostafa, Alshaer, Fayez, Mimish, Layth, Almasood, Ali, AlHabeeb, Waleed, AlGhamdi, Saleh, Ghabashi, Abdullah, Asfina, KaziNur, Altaradi, Hani, Alnobani, Omar, Alkamel, Nour, Thalib, Lukman
• Format: Journal Article
• Language: English
• Published: United States 01.10.2015
• Subjects: Acute Disease; Adult; Age Factors; Aged; Chronic Disease; Comorbidity; Female; Heart Failure - diagnosis; Heart Failure - mortality; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Registries; Risk Factors; Saudi Arabia - epidemiology; Sex Factors; Time Factors; Saudi Arabia; Saudi Arabia; registry; acute heart failure; HEARTS; middle east
• ISSN: 1940-1574
• DOI: 10.1177/0003319714563138

The heart function assessment registry trial in Saudi Arabia (HEARTS) is a national multicenter project that compared de novo versus acute-on-chronic heart failure (ACHF). This is a prospective registry in 18 hospitals in Saudi Arabia between October 2009 and December 2010. The study enrolled 2610 patients: 940 (36%) de novo and 1670 (64%) ACHF. Patients with ACHF were significantly older (62.2 vs 60 years), less likely to be males (64% vs 69%) or smokers (31.6% vs 36.7%), and more likely to have history of diabetes mellitus (65.7% vs 61.3%), hypertension (74% vs 65%), and severe left ventricular dysfunction (52% vs 40%). The ACHF group had a higher adjusted 3-year mortality rate (hazard ratio, 1.6; 95% confidence interval [CI] 1.3-2.0; P < .001). Patients with ACHF had significantly higher long-term mortality rates than those with de novo acute heart failure (HF). Multidisciplinary HF disease management programs are highly needed for such high-risk populations.