Effectiveness of seasonal 2012/13 vaccine in preventing laboratory-confirmed influenza infection in primary care in the United Kingdom: mid-season analysis 2012/13

• Published in: Euro surveillance : bulletin européen sur les maladies transmissibles Vol. 18; no. 5; p. 1
• Main Authors: McMenamin, J, Andrews, N, Robertson, C, Fleming, Dm, Durnall, H, von Wissmann, B, Ellis, J, Lackenby, A, Cottrell, S, Smyth, B, Zambon, M, Moore, C, Watson, Jm, Pebody, Rg
• Format: Journal Article
• Language: English
• Published: Sweden Centre Europeen pour la Surveillance Epidemiologique du SIDA (European Centre for the Epidemiological Monitoring of AIDS) 31.01.2013
• Subjects: Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Case-Control Studies; Child; Child, Preschool; Disease prevention; Effectiveness studies; Female; Humans; Immunization; Infant; Infant, Newborn; Influenza; Influenza A virus - genetics; Influenza A virus - immunology; Influenza A virus - isolation & purification; Influenza B virus - genetics; Influenza B virus - immunology; Influenza B virus - isolation & purification; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza, Human - diagnosis; Influenza, Human - epidemiology; Influenza, Human - prevention & control; Influenza, Human - virology; Logistic Models; Male; Middle Aged; Odds Ratio; Primary care; Primary Health Care; Real-Time Polymerase Chain Reaction; Seasons; Sentinel Surveillance; Surveys and Questionnaires; Treatment Outcome; United Kingdom - epidemiology; Vaccination - statistics & numerical data; Vaccines; Young Adult; United Kingdom > UK
• ISSN: 1560-7917; 1025-496X; 1560-7917
• DOI: 10.2807/ese.18.05.20393-en

The early experience of the United Kingdom (UK) is that influenza B has dominated the influenza 2012/13 season. Overall trivalent influenza vaccine (TIV) adjusted vaccine effectiveness (VE) against all laboratory-confirmed influenza in primary care was 51% (95% confidence interval (CI): 27% to 68%); TIV adjusted VE against influenza A alone or influenza B alone was 49% (95% CI: -2% to 75%) and 52% (95% CI: 23% to 70%) respectively. Vaccination remains the best protection against influenza.