Preliminary Study of the Impact of Single-Nucleotide Polymorphisms of IL-1α, IL-1β and TNF-α Genes on the Occurrence, Severity and Treatment Effectiveness of the Major Depressive Disorder

• Published in: Cellular and molecular neurobiology Vol. 40; no. 6; pp. 1049 - 1056
• Main Authors: Bialek, Katarzyna, Czarny, Piotr, Watala, Cezary, Synowiec, Ewelina, Wigner, Paulina, Bijak, Michal, Talarowska, Monika, Galecki, Piotr, Szemraj, Janusz, Sliwinski, Tomasz
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.08.2020; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Brief Communication; Cell Biology; Depressive Disorder, Major - epidemiology; Depressive Disorder, Major - genetics; Epigenesis, Genetic; Genes; Genetic Predisposition to Disease; Humans; IL-1β; Interleukin-1alpha - genetics; Interleukin-1beta - genetics; Mental depression; Neurobiology; Neurosciences; Polymorphism, Single Nucleotide - genetics; Severity of Illness Index; Single-nucleotide polymorphism; Treatment Outcome; Tumor Necrosis Factor-alpha - genetics; Tumor necrosis factor-α; Inflammation; Single nucleotide polymorphism; Major depressive disorder; Cytokine
• ISSN: 0272-4340; 1573-6830
• DOI: 10.1007/s10571-019-00782-5

The purpose of the preliminary study was to determine whether the occurrence of certain SNPs of genes encoding IL-1α , IL-1β , and TNF-α is associated with the development of depression. Five polymorphisms were selected: i.e. c.-1560G > C— IL-1β (rs1143623), c. -118 C > T— IL-1β (rs1143627), c.340G > T— IL-1α (rs17561), c.-1211T > C— TNF-α (rs1799964) and c.-488G > A— TNF-α (rs1800629). These were analyzed using TaqMan probes. The genotypes of the analyzed polymorphisms were found to be associated with disease severity and may affect the effectiveness of antidepressant therapy. In addition, the gene–gene analysis confirmed that combined genotypes of investigated SNPs may modulate the risk of depression.