Long non-coding RNAs and splicing

In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently. In the second half of the review, I speculate why spli...

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Bibliographic Details
Published inEssays in biochemistry
Main Author Staněk, David
Format Journal Article
LanguageEnglish
Published England 27.10.2021
Subjects
SR proteins
spliceosomes
large intervening non-coding RNA
splicing
snRNP
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Summary:In this review I focus on the role of splicing in long non-coding RNA (lncRNA) life. First, I summarize differences between the splicing efficiency of protein-coding genes and lncRNAs and discuss why non-coding RNAs are spliced less efficiently. In the second half of the review, I speculate why splice sites are the most conserved sequences in lncRNAs and what additional roles could splicing play in lncRNA metabolism. I discuss the hypothesis that the splicing machinery can, besides its dominant role in intron removal and exon joining, protect cells from undesired transcripts.
ISSN:1744-1358
DOI:10.1042/EBC20200087