Microbiology of destructive periodontal disease in adolescent patients with congenital neutropenia. A report of 3 cases

• Published in: Journal of clinical periodontology Vol. 27; no. 11; pp. 793 - 798
• Main Authors: van Winkelhoff, A J, Schouten-van Meeteren, A Y, Baart, J A, Vandenbroucke-Grauls, C M
• Format: Journal Article
• Language: English
• Published: United States 01.11.2000
• Subjects: Actinobacillus Infections - transmission; Adolescent; Aggregatibacter actinomycetemcomitans - pathogenicity; Dentistry; DNA Fingerprinting; DNA, Bacterial - analysis; Fathers; Female; Genetic Predisposition to Disease; Gingivitis - microbiology; Humans; Infectious Disease Transmission, Vertical; Male; Neutropenia - complications; Neutropenia - congenital; Periodontal Pocket - microbiology; Periodontitis - etiology; Periodontitis - microbiology; Porphyromonas gingivalis - pathogenicity
• ISSN: 0303-6979; 1600-051X
• DOI: 10.1034/j.1600-051x.2000.027011793.x

Congenital neutropenia is one condition that may predispose for destructive periodontal disease at a young age. In this report, we describe the microbiology of 3 adolescent patients with congenital neutropenia two of whom suffered from severe periodontitis. Microbiological testing of the parents was also performed in 1 case. DNA fingerprinting was used to study transmission of putative periodontal pathogens in this case. From 1 patient with periodontitis, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis were isolated; a 2nd periodontitis patient was infected with P. gingivalis. A 3rd patient had gingivitis only and no A. actinomycetemcomitans or P. gingivalis were found. Using the amplified fragment length polymorphism DNA fingerprinting technique, bacterial transmission between the father and a patient was shown for A. actinomycetemcomitans but not for P. gingivalis.