Squamous cell carcinoma in situ arising in inflammatory cloacogenic polyps: Report of two cases with PCR analysis for HPV DNA

• Published in: Pathology Vol. 33; no. 3; pp. 312 - 314
• Main Authors: JAWORSKI, Richard C, BIANKIN, Sandra A, BAIRD, Phillip J
• Format: Journal Article
• Language: English
• Published: London Taylor and Francis 01.08.2001
• Subjects: Adult; Anus Neoplasms - pathology; Anus Neoplasms - virology; Biological and medical sciences; Carcinoma in Situ - pathology; Carcinoma in Situ - virology; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - virology; Colonic Polyps - pathology; Colonic Polyps - virology; DNA, Viral - analysis; Female; Gastroenterology. Liver. Pancreas. Abdomen; Human papillomavirus; Humans; Medical sciences; Neoplasms, Second Primary - pathology; Neoplasms, Second Primary - virology; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - complications; Papillomavirus Infections - pathology; Polymerase Chain Reaction; Rectal Prolapse - complications; Rectal Prolapse - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Syndrome; Tumor Virus Infections - complications; Tumor Virus Infections - pathology; Tumors; Ulcer - complications; Ulcer - pathology; Human; Immunohistochemistry; Squamous cell carcinoma; Carcinoma in situ; Papovaviridae; Malignant tumor; Inflammatory pseudotumor; Papillomavirus; Virus; Case study; Polymerase chain reaction; Pathology; Human papillomavirus; DNA; Malignant transformation; Rectum; Digestive diseases; Adult; Female; Molecular biology; Anorectal disease; Polyp
• ISSN: 0031-3025; 1465-3931
• DOI: 10.1080/00313020120062901

Inflammatory cloacogenic polyp (ICP) is regarded as part of the spectrum of pathological changes encountered in mucosal prolapse syndrome (MPS)/solitary rectal ulcer. We present the clinicopathological features of two females with squamous cell carcinoma in situ arising in their ICPs. Human papillomavirus (HPV) type 16 was demonstrated in the areas of squamous carcinoma in situ in both polyps by polymerase chain reaction. These cases highlight the need for close scrutiny of the squamous components of these lesions.