Inhibition by somatostatin of ACTH secretion in Nelson's syndrome

Somatostatin (GHIF), when administered as a 1-hr infusion (500 mug/hr) to 5 patients with Nelson's Syndrome;resulted in a sustained, progressive fall in plasma ACTH in each patient to 40% to 71% of basal values with a return toward initail levels after cessation of the infusion. The meanreducti...

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Bibliographic Details
Published inThe journal of clinical endocrinology and metabolism Vol. 40; no. 6; p. 1125
Main Authors Tyrrell, J B, Lorenzi, M, Gerich, J E, Forsham, P H
Format Journal Article
LanguageEnglish
Published United States 01.06.1975
Subjects
Adenoma - physiopathology
Adrenocorticotropic Hormone - blood
Adult
Female
Humans
Infusions, Parenteral
Male
Pituitary Neoplasms - physiopathology
Somatostatin - administration & dosage
Syndrome
Time Factors
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Summary:Somatostatin (GHIF), when administered as a 1-hr infusion (500 mug/hr) to 5 patients with Nelson's Syndrome;resulted in a sustained, progressive fall in plasma ACTH in each patient to 40% to 71% of basal values with a return toward initail levels after cessation of the infusion. The meanreduction in plasma ADTH was 48% (p less than 0.005). These finding suggest that GHIF receptors not fuctional or present in normal pituitary tissue are present in ACTH-producing pituitary tumors.
ISSN:0021-972X
1945-7197
DOI:10.1210/jcem-40-6-1125