Two cases of gastric cancer with peritoneal carcinomatosis successfully responding to combination chemotherapy of S-1 and cisplatin, leading to clinical complete response

We report two cases of gastric cancer with peritoneal carcinomatosis successfully responding to combination chemotherapy of S-1 and cisplatin, leading to a clinical complete response (cCR). In case 1, a 60-year-old woman achieved a cCR after 6 cycles of S-1 and cisplatin. Eight cycles of S-1 and cis...

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Bibliographic Details
Published inInternational cancer conference journal Vol. 2; no. 4; pp. 201 - 205
Main Authors Suzuki, Shuhei, Ito, Yuriko, Fukui, Tadahisa, Orihara, Mika, Nakamura, Sho, Takahashi, Masahiro, Fujimoto, Hiroto, Kimura, Wataru, Yoshioka, Takashi
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.10.2013
Springer Nature B.V
Subjects
Ascites
Biopsy
Case Report
Case reports
Chemotherapy
Cisplatin
Family medical history
Gastric cancer
Lymphatic system
Medical prognosis
Medicine
Medicine & Public Health
Metastases
Metastasis
Oncology
Patients
Peritoneum
Surgery
Surgical Oncology
Tomography
Japan
Chemotherapy
Gastric cancer
S-1
Clinical complete response
Cisplatin
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Summary:We report two cases of gastric cancer with peritoneal carcinomatosis successfully responding to combination chemotherapy of S-1 and cisplatin, leading to a clinical complete response (cCR). In case 1, a 60-year-old woman achieved a cCR after 6 cycles of S-1 and cisplatin. Eight cycles of S-1 and cisplatin and 16 cycles of S-1 alone were administered. Since treatment with S-1 alone, only observation has been performed with no recurrence. In case 2, a 63-year-old man achieved cCR after 2 cycles of S-1 and cisplatin chemotherapy. After 8 cycles of chemotherapy, cCR was confirmed, and a curative operation was performed. After surgery, a small number of viable cells were found in the pathological examination. Fifty-four reports of cCR cases of advanced non-resectable or metastatic gastric cancer with chemotherapy have been published, but none mentioned the treatment options after cCR. In this report, we show two patients choosing different paths after achieving cCR by chemotherapy. In our surgical case, residues of pathologically viable cancer cells were confirmed, so surgery might be recommended after cCR, but further investigation will be needed.
ISSN:2192-3183
2192-3183
DOI:10.1007/s13691-013-0090-1