Skin-type adnexal tumor with trichoblastic germinative differentiation in the breast: a case report

• Published in: International journal of surgical pathology Vol. 19; no. 4; p. 527
• Main Authors: Gököz, Ozay, Presenti, Loretta, Gambacorta, Giuseppina, Zolfanelli, Federica, Tricarico, Rossella, Nistri, Roberto, Baroni, Gianna, Bianchi, Simonetta, Massi, Daniela
• Format: Journal Article
• Language: English
• Published: United States 01.08.2011
• Subjects: beta Catenin - genetics; Biomarkers, Tumor - metabolism; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Breast Neoplasms - surgery; Cell Transformation, Neoplastic; Female; Hair Diseases - genetics; Hair Diseases - metabolism; Hair Diseases - pathology; Hair Diseases - surgery; Hair Follicle - pathology; Humans; Middle Aged; Mutation, Missense; Neoplasms, Adnexal and Skin Appendage - genetics; Neoplasms, Adnexal and Skin Appendage - metabolism; Neoplasms, Adnexal and Skin Appendage - pathology; Neoplasms, Adnexal and Skin Appendage - surgery
• ISSN: 1940-2465
• DOI: 10.1177/1066896909337383

Adnexal tumors with follicular differentiation in the breast parenchyma are rarely encountered. The authors present a unique case arising in a 64-year-old woman, in whom they observed composite differentiation toward follicular germinative cells of the hair follicle with focal areas of outer root sheath differentiation and pilar-type keratinization. The histogenesis of this tumor is analyzed in light of the peculiar pathological, immunohistochemical, and molecular genetic findings.