Genetic susceptibility to multiple sclerosis

Previous studies of histocompatibility (HLA) types in multiple sclerosis (MS) families did not provide convincing proof of an HLA-linked susceptibility factor. In 12 families we studied, all MS cases in each family shared at least one chromosome. The probability of this occurring in the absence of g...

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Bibliographic Details
Published inNeurology Vol. 29; no. 10; p. 1354
Main Authors Visscher, B R, Detels, R, Dudley, J, Haile, R W, Malmgren, R M, Terasaki, P I, Park, M S
Format Journal Article
LanguageEnglish
Published United States 01.10.1979
Subjects
Female
Haploidy
HLA Antigens - analysis
HLA Antigens - genetics
Humans
Male
Multiple Sclerosis - genetics
Multiple Sclerosis - immunology
Pedigree
Recombination, Genetic
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Summary:Previous studies of histocompatibility (HLA) types in multiple sclerosis (MS) families did not provide convincing proof of an HLA-linked susceptibility factor. In 12 families we studied, all MS cases in each family shared at least one chromosome. The probability of this occurring in the absence of genetic linkage is approximately 0.001. The estimated penetrance is 5 percent, implying that the genetic susceptibility factor may be a necessary but not a sufficient cause of MS. Additional studies are needed to identify other differences between affected and unaffected susceptible individuals.
ISSN:0028-3878
DOI:10.1212/WNL.29.10.1354