The role of gamma/delta T cells in immunity to infection and regulation of inflammation

The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the respons...

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Bibliographic Details
Published inImmunologic research Vol. 29; no. 1-3; pp. 293 - 302
Main Author Ziegler, H Kirk
Format Journal Article
LanguageEnglish
Published United States 2004
Subjects
Animals
Bacterial Infections - immunology
CD4-Positive T-Lymphocytes - immunology
CD8-Positive T-Lymphocytes - immunology
Infection - immunology
Inflammation - immunology
Mice
Receptors, Antigen, T-Cell, gamma-delta - analysis
Receptors, Antigen, T-Cell, gamma-delta - immunology
T-Lymphocyte Subsets - immunology
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Summary:The role of gamma/delta T cells in immunity to bacterial infection and control of inflammation is discussed. Special emphasis is placed on the use of murine models in which various aspects of immune function can be monitored in the absence of gamma/delta T cells. Issues discussed include the response to and control of cytokine production by gamma/delta T cells. Especially relevant is the apparent paradox that gamma/delta T cells play both pro-inflammatory and antiinflammatory roles in response to infection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0257-277X
1559-0755
0257-277X
DOI:10.1385/IR:29:1-3:293