The relationship between alexithymia, reading the mind in the eyes and cognition in patients with multiple sclerosis

• Published in: Multiple sclerosis and related disorders Vol. 68; p. 104196
• Main Authors: Karpuz Seren, Burcu, Acikgoz, Mustafa, Piri Cinar, Bilge, Aciman Demirel, Esra, Celebi, Ulufer, Atasoy, Hüseyin Tugrul
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2022
• Subjects: Affective Symptoms - etiology; Affective Symptoms - psychology; Alexithymia; Cognition; Fatigue - complications; Humans; Multiple sclerosis; Multiple Sclerosis - complications; Multiple Sclerosis - psychology; Neuropsychological Tests; Quality of Life; Reading the mind in the eyes; Multiple sclerosis; Cognition; Reading the mind in the eyes; Alexithymia
• ISSN: 2211-0348; 2211-0356
• DOI: 10.1016/j.msard.2022.104196

•Alexithymia is more common in people with multiple sclerosis (PwMS) than in the normal population.•Alexithymia, depression and cognitive impairment affect theory of mind in PwMS.•Social cognitive impairment should also be evaluated in the follow-up of PwMS.•Alexithymia is associated with quality of life, depression and anxiety. The purpose of this study was to determine the frequency of alexithymia, difficulty in recognizing one's own and others’ emotions, to determine the ability to read the mind in the eyes that evaluates the emotions of others, and to assess the relationship between these parameters and demographic characteristics, cognition, anxiety and depression in people with multiple sclerosis (PwMS). Seventy patients presenting to the neurology clinic and diagnosed with MS and 70 healthy volunteers with similar demographic characteristics were included in the study. The California Verbal Learning Test II (CVLT II), Symbol Digit Modalities Test (SDMT), Revised Brief Visuospatial Memory Test (BVMT-R), and Trail-Making Test (TMT) were applied to determine all participants’ cognitive status. All participants were also administered Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Toronto Alexithymia Scale-20 (TAS-20), Reading the Mind in the Eyes Test (RMET), Fatigue Impact Scale (FIS) and Short Form 36 Health Survey (SF-36) for quality of life. Alexithymia levels were higher in the PwMS than in the control group, 24.2% of the PwMS and 4.2% of the control group being alexithymic. The PwMS group exhibited poorer performance on all cognitive tests and in BDI, BAI, FIS and SF-36 scale scores than the control group. No difference was determined between the groups’ RMET scores. Depression and anxiety levels increased in line with alexithymia levels in the PwMS group, while RMET scores decreased. No association was determined between alexithymia levels and age, sex, duration of disease, degree of disability, cognition, or fatigue. RMET scores were not affected by age, sex, duration of disease, degree of disability, anxiety, or fatigue, but were lower among individuals with poor cognition and in depressive patients. Neuropsychiatric symptoms have been the subject of considerable research in MS in recent years and these clinical characteristics in patients have begun being closely monitored. PwMS are capable of experiencing difficulty in identifying emotions in themselves and others, and their social lives can be affected. In addition, the fact that this exhibits an association with cognition based on RMET is particularly noteworthy.