Spatial gradients controlling spindle assembly

The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and addres...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 43; no. 1; p. 7
Main Authors Weaver, Lesley N, Walczak, Claire E
Format Journal Article
LanguageEnglish
Published England 01.02.2015
Subjects
Animals
Chromosome Segregation
Chromosomes - physiology
Humans
Microtubules - metabolism
Mitosis
Protein Multimerization
Protein Transport
Spindle Apparatus - metabolism
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Summary:The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function.
ISSN:1470-8752
DOI:10.1042/BST20140243