Spatial gradients controlling spindle assembly
The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and addres...
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Published in | Biochemical Society transactions Vol. 43; no. 1; p. 7 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
England
01.02.2015
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Subjects | |
Online Access | Get more information |
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Summary: | The mitotic spindle is the macromolecular machine utilized to accurately segregate chromosomes in cells. How this self-organized structure assembles is a key aspect of understanding spindle morphogenesis. In the present review, we focus on understanding mechanisms of spindle self-assembly and address how subcellular signalling gradients, such as Ran-GTP and Aurora B, contribute to spindle organization and function. |
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ISSN: | 1470-8752 |
DOI: | 10.1042/BST20140243 |