MicroRNA expression profiling of human islets from individuals with and without type 2 diabetes: promises and pitfalls

Recent studies in mouse, involving the β-cell-specific deletion of Dicer1, have highlighted the crucial role of miRNAs (microRNAs) in regulating insulin secretion and consequently Type 2 diabetes. Identifying the individual miRNAs involved in human islet dysfunction may be of diagnostic and therapeu...

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Bibliographic Details
Published inBiochemical Society transactions Vol. 40; no. 4; p. 800
Main Authors Locke, Jonathan M, Harries, Lorna W
Format Journal Article
LanguageEnglish
Published England 01.08.2012
Subjects
Diabetes Mellitus, Type 2 - genetics
Humans
Insulin-Secreting Cells - metabolism
Islets of Langerhans - metabolism
MicroRNAs - genetics
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Summary:Recent studies in mouse, involving the β-cell-specific deletion of Dicer1, have highlighted the crucial role of miRNAs (microRNAs) in regulating insulin secretion and consequently Type 2 diabetes. Identifying the individual miRNAs involved in human islet dysfunction may be of diagnostic and therapeutic interest. miRNA expression profiling of human islets isolated from donors with and without Type 2 diabetes may represent one of the first steps in the discovery of these specific miRNAs. The present review discusses some of the potential pitfalls and promises of such an approach.
ISSN:1470-8752
DOI:10.1042/BST20120049