Synthesis, Characterization and Molecular Structure of 2-Pyridyl-formamide N(4)-Dimethylthiosemicarbazone and Some Five-Coordinated Zinc(II) and Cadmium(II) Complexes

• Published in: Zeitschrift für Naturforschung. B, A journal of chemical sciences Vol. 56; no. 12; pp. 1297 - 1305
• Main Authors: Bermejo, Elena, Castiñeiras, Alfonso, Fostiak, Larissa M., García, Isabel, Llamas-Saiz, Antonio L., Swearingen, John K., West, Douglas X
• Format: Journal Article
• Language: English
• Published: BERLIN Verlag der Zeitschrift für Naturforschung 01.12.2001; Walter De Gruyter
• Subjects: 2-Pyridyl-formamide; Chemistry; Chemistry, Inorganic & Nuclear; Chemistry, Organic; Physical Sciences; Science & Technology; Thiosemicarbazones; Zinc; COPPER(II) COMPLEXES; 2-PYRIDINEFORMAMIDE THIOSEMICARBAZONE; 2-pyridyl-formamide; NICKEL(II) COMPLEXES; 2-FORMYLPYRIDINE; thiosemicarbazones; CRYSTAL; zinc; CYTOTOXICITY
• ISSN: 0932-0776; 1865-7117
• DOI: 10.1515/znb-2001-1208

Sodium in dry methanol reduces 2-cyanopyridine in the presence of N(4)-dimethylthiosemicarbazide to produce 2-pyridyl-formamide N(4)-dimethylthiosemicarbazone, HAm4DM. Com­plexes with zinc(II) and cadmium(II) of formulae [M(Am4DM)(OAc)] and [M(HAm4DM)X ] (M = Zn or Cd, X = Cl, Br or I) have been prepared and characterized by spectro­scopic techniques. In addition, the crystal structures of HAm4DM, [Zn(HAm4DM)Br ], and [Cd(HAm4DM)l ] DMSO have been solved. HAm4DM is in the zwitterionic form with a hydrogen bonding interaction between the iminium hydrogen and the thiolato sulfur atom. Co­ ordination of the neutral thiosemicarbazone ligand is via the pyridyl nitrogen, imine nitrogen and thione sulfur atoms, while the anionic ligand in [M(Am4DM)(OAc)] coordinates with the same two nitrogen atoms and a thiolato sulfur atom. The [M(HAm4DM)X ] complexes are 5-coordinate with the tridentate thiosemicarbazone and two halogen ligands approaching a square pyramidal stereochemistry.