Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy

We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to...

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Bibliographic Details
Published inClinical infectious diseases Vol. 78; no. 1; p. 94
Main Authors Amali, Aseervatham Anusha, Ravikumar, Sharada, Chew, Wei Leong, Tan, Zhaohong, Sam, Qi Hui, Chen, Kaiwen W, Boucher, Dave, MacLaren, Graeme, Chai, Louis Yi Ann
Format Journal Article
LanguageEnglish
Published United States 25.01.2024
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Summary:We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome.
ISSN:1537-6591
DOI:10.1093/cid/ciad517