Extracorporeal Membrane Oxygenation-Dependent Fulminant Melioidosis From Caspase 4 Mutation Reversed by Interferon Gamma Therapy
We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to...
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Published in | Clinical infectious diseases Vol. 78; no. 1; p. 94 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
25.01.2024
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Subjects | |
Online Access | Get more information |
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Summary: | We describe bedside-to-bench immunological and genetic elucidation of defective pyroptosis attributable to novel caspase 4 defect mediating pathogen-triggered inflammatory programmed cell death, in the setting of severe pneumonia and abscess-forming melioidosis in an overtly healthy host failing to clear Burkholderia pseudomallei infection, and how targeted adjunctive biological therapy led to a successful outcome. |
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ISSN: | 1537-6591 |
DOI: | 10.1093/cid/ciad517 |