The efficacy of organo-selenium conjugated cellulose polymer dressing to inhibit Candida albicans biofilm formation

Selenium covalently bonded to cellulose can catalyze the formation of superoxide radicals. Candida albicans, colonizes epithelial surfaces and can be a fatal infection in immunocompromised people. In this study, we demonstrated the ability of organo-selenium, covalently attached to cotton textile dr...

Full description

Saved in:
Bibliographic Details
Published inJournal of microbiological methods Vol. 202; p. 106598
Main Authors Jacobo, Unique, Kopel, Jonathan, Reed, John, Patel, Shruti, Jain, Suyash, Tran, Phat, Abidi, Noureddine, Bergfeld, Nicholas, Reid, Ted
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2022
Subjects
Antibiotic resistance
Antifungal Agents - pharmacology
Antimicrobials
Bandages
Biofilms
Candida albicans
Cellulose - pharmacology
Humans
Organo-selenium compounds
Polymers
Selenium
Selenium - pharmacology
Organo-selenium compounds
Candida albicans
Selenium
Antimicrobials
Antibiotic resistance
Online AccessGet full text

Cover

More Information
Summary:Selenium covalently bonded to cellulose can catalyze the formation of superoxide radicals. Candida albicans, colonizes epithelial surfaces and can be a fatal infection in immunocompromised people. In this study, we demonstrated the ability of organo-selenium, covalently attached to cotton textile dressings to kill C. albicans biofilms. •We examined the efficacy of selenium coated cotton textile dressings againstC. albicans in open wounds. We showed:•Cotton textile materials can be incorporated with selenium monomers•Textiles attached with 1.0% and 8% selenium solution inhibits over 8 logs of C. albicans biofilm formation•Attaching OS to textiles is stable for over 2 years soaking in PBS and still exhibits inhibition of biofilm formation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0167-7012
1872-8359
DOI:10.1016/j.mimet.2022.106598