Cognition, oxidative stress and vitamin B12 levels evaluation on patients under long-term omeprazole use

To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months. A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % femal...

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Published inJournal of pharmacy and pharmacology Vol. 74; no. 4; p. 547
Main Authors Dries, Larissa Selbach, Haefliger, Rochelli, Seibert, Bruna Sherer, de Lima, Angélica Gewehr, Cardoso, Caroline de Oliveira, Perassolo, Magda Susana
Format Journal Article
LanguageEnglish
Published England 20.04.2022
Subjects
Aged
Antioxidants - analysis
Case-Control Studies
Cognition
Female
Glutathione Peroxidase
Humans
Male
Middle Aged
Omeprazole - adverse effects
Oxidative Stress
Superoxide Dismutase - metabolism
Vitamin B 12
omeprazole
cognitive impairment
vitamin B12
oxidative stress
PPIs
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Summary:To evaluate the differences concerning cognitive performance, oxidative stress and vitamin B12 levels in omeprazole users under treatment for longer than six months. A case-control study was developed with 44 omeprazole users (OU; 81.8 % female, 66 ± 8.7 years old) and 35 nonusers (NOU; 88.6 % female, 62 ± 8.7 years old). The cognitive ability was assessed through tests approaching attention, memory and executive functions. The vitamin B12 was dosage using a chemiluminescent immunoassay and oxidative stress analysis, based on the evaluation of malondialdehyde, enzymatic activity of extracellular superoxide dismutase, glutathione peroxidase, catalase and the ferric reducing antioxidant power in plasma. A significant increase of the ferric reducing antioxidant power [omeprazole users (OU) group = 1690 µM ± 441 and nonusers (NOU) group = 1308 ± 616; P value=0.002] and a decrease on glutathione peroxidase levels [OU group = 0.534 (0.27-10.63) and NOU group = 71.86 (14.36-173.1); P value=0.006] were found on omeprazole users group, as well as differences on cognitive performance, with impairments on executive functions, automatic and attentional processing. Long-term use of omeprazole is suggested to induce an oxidative stress condition, which causes neurotoxicity and cognitive decline.
ISSN:2042-7158
DOI:10.1093/jpp/rgab001