Palladium-catalysed Grignard cross-coupling using highly concentrated Grignards in methyl-tetrahydrofuran

The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was als...

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Published inGreen chemistry : an international journal and green chemistry resource : GC Vol. 12; no. 3; pp. 381 - 383
Main Authors MILTON, Edward J, CLARKE, Matthew L
Format Journal Article
LanguageEnglish
Published Cambridge Royal Society of Chemistry 01.01.2010
Subjects
Catalysis
Catalysts
Catalysts: preparations and properties
Chemistry
Exact sciences and technology
General and physical chemistry
Kinetics and mechanisms
Organic chemistry
Reactivity and mechanisms
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Catalytic reaction
Transition element complexes
Furan derivatives
Microwave
Palladium complex
Transition metal
Oxygen heterocycle
Metallocene
Tetrahydrofurane
Ferrocene
Iron Organic compounds
Grignard reagent
Cross reaction
Chemical synthesis
Platinoid
Solvent
Catalyst
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Summary:The cross-coupling of Grignard reagents at 5 molar concentration in methyl-tetrahydrofuran with no added reaction solvents can be achieved with the appropriate matching of catalyst to substrate, significantly reducing solvent use when compared to a typical protocol in tetrahydrofuran. Me-THF was also used in an improved microwave accelerated synthesis of the [Pd(L)Cl2] pre-catalysts from sodium tetrachloropalladate in very high yield.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1463-9262
1463-9270
DOI:10.1039/b921026a