Limited value of KAI1/CD82 protein expression as a prognostic marker in human gastric cancer

• Published in: Disease markers Vol. 32; no. 6; pp. 337 - 342
• Main Authors: Knoener, Maximilian, Krech, Till, Puls, Florian, Lehmann, Ulrich, Kreipe, Hans, Christgen, Matthias
• Format: Journal Article
• Language: English
• Published: United States 2012
• Subjects: Aged; Biomarkers, Tumor - metabolism; Female; Follow-Up Studies; Humans; Immunohistochemistry; Kangai-1 Protein - metabolism; Kaplan-Meier Estimate; Lymph Nodes - pathology; Lymphatic Metastasis - pathology; Male; Prognosis; Protein Array Analysis - methods; Stomach Neoplasms - diagnosis; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Time Factors
• ISSN: 0278-0240; 1875-8630
• DOI: 10.1155/2012/737132

The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n=271) with a mean clinical follow-up time of 48 months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p=0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p=0.0222), metastatic lymph node involvement (p=0.0018) and a higher clinical tumor stage (p=0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p=0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.