Synthetic utility of 4-acetyl-3-arylsydnones: synthesis, spectral characterisation and antimicrobial activity of 3-aryl-4-[(2 ',3 '-dihydrospiro-1 ',4 '-benzodiazepine-5 ',[3 ''-3 '' H]-2 ''-oxindol]-(1 '' H))-7 '-yl] sydnones

3-Aryl-4-[3'-hydroxy-2'oxo)-3'-indol]acetylsydnones IIa-n have been synthesised from 4-acetyl-3-arylsdnones Ia-n and isatin. These beta -hydroxy derivatives were readily converted into the corresponding alpha, beta -unsaturated ketones IIIa-n which were further condensed with 1,2-phen...

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Bibliographic Details
Published inJournal of chemical research Vol. 2000; no. 12; pp. 546 - 547
Main Authors Kavali, Badami, BV
Format Journal Article
LanguageEnglish
Published LONDON Sage 01.12.2000
Subjects
Chemistry
Chemistry, Multidisciplinary
Physical Sciences
Science & Technology
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Summary:3-Aryl-4-[3'-hydroxy-2'oxo)-3'-indol]acetylsydnones IIa-n have been synthesised from 4-acetyl-3-arylsdnones Ia-n and isatin. These beta -hydroxy derivatives were readily converted into the corresponding alpha, beta -unsaturated ketones IIIa-n which were further condensed with 1,2-phenylenediamine to give the 3-aryl-4-[2',3'-dihydrospiro-1',4'-benzodiazepine-5',3 "-[3 "H]-2 " -oxindol-)1 "H))-7'-yl]sydnones IVa-n. All the compounds have been evaluated for their in vitro growth inhibitory activity against few microbes.
ISSN:1747-5198
2047-6507
DOI:10.3184/030823400103166328