A Comparison of Complete Genome Sequences of a Rabies Virus Chinese Isolate SH06 with the Vaccine Strains

• Published in: Virologica Sinica Vol. 24; no. 6; pp. 529 - 536
• Main Authors: Meng, Sheng-li, Xu, Ge-Lin, Wu, Jie, Yang, Xiao-Ming, Yan, Jia-Xin
• Format: Journal Article
• Language: English
• Published: Heidelberg SP Wuhan Institute of Virology, CAS 01.12.2009; KeAi Publishing Communications Ltd; Center of Rabies Diagnosis, Wuhan Institute of Biological Products, Wuhan 430060, China
• Subjects: Amino acid sequence; Biochemistry; Biomedical and Life Sciences; Biomedicine; GenBank; Genomes; Homology; Medical Microbiology; Microbial Genetics and Genomics; Microbiology; Nucleotide sequence; Oncology; Phylogenetics; Phylogeny; Rabies; Strains (organisms); Vaccines; Virology; 中国株; 基因组序列; 氨基酸序列; 狂犬病毒; 狂犬病病毒; 疫苗株; 系统发育分析; Complete genome sequence; Phylogenetic analysis; R373; Rabies virus
• ISSN: 1674-0769; 1995-820X
• DOI: 10.1007/s12250-009-3030-7

In this study, we determined the complete nucleotide and deduced amino acid sequence of a primary isolate of rabies virus （SH06） obtained from the brain of a rabid dog. The overall length of the genome was 11 924 nucleotides. Comparison of the genomic sequence showed the homology of SH06 at nucleotide level with full-length genomes of reference vaccine strains ranged from 82.2% with the PV strain to 86.9% with the CTN strain. A full-length genome-based phylogenetic analysis was performed with sequences available from GenBank. Phylogenetic analysis of the complete genome sequences indicated that the SH06 exhibited the highest homology with rabies street virus BD06 and CTN vaccine strain originated from China.