Synthetic Strategies for Hydrazinyl Thiazole Derivatives

Hydrazinyl thiazole is frequently encountered in natural as well as in synthetic compounds. It is also an important pharmacophore and has some other useful applications. In this review article, we have compiled different green synthetic procedures for the synthesis of hydrazinyl thiazole derivatives...

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Bibliographic Details
Published inChemistrySelect (Weinheim) Vol. 5; no. 48; pp. 15153 - 15166
Main Authors Dey, Sovan, Das, Arindam, Hossain, Md. Firoj
Format Journal Article
LanguageEnglish
Published 30.12.2020
Subjects
Green Chemistry
Hydrazinyl Thiazole
Multicomponent Reactions
Phenacyl bromide
Thiosemicarbazide
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Summary:Hydrazinyl thiazole is frequently encountered in natural as well as in synthetic compounds. It is also an important pharmacophore and has some other useful applications. In this review article, we have compiled different green synthetic procedures for the synthesis of hydrazinyl thiazole derivatives. Also, the critical analysis of different synthetic schemes will help to understand the lacks in developed procedures and to develop new methodologies regarding its synthesis, specially using heterogeneous organocatalyst and photocatalyst. Hydrazinyl Thiazole, an important pharmacophore has been synthesized using different methodologies by different research groups. Here we have compiled different methodologies and also pointed out the advantages and disadvantages of reported protocols along with future scopes for further development in synthetic procedure.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202003993