Chordoma: cytologic and immunocytochemical study of four cases

We present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine-needle aspiration biopsies. The physaliferous cells in signet-ring, pearl-like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrange...

Full description

Saved in:
Bibliographic Details
Published inDiagnostic cytopathology Vol. 2; no. 1; p. 55
Main Authors Kontozoglou, T, Qizilbash, A H, Sianos, J, Stead, R
Format Journal Article
LanguageEnglish
Published United States 01.01.1986
Subjects
Adult
Aged
Antigens - analysis
Biopsy, Needle
Brain Neoplasms - diagnosis
Brain Neoplasms - pathology
Carcinoembryonic Antigen - analysis
Chordoma - diagnosis
Chordoma - pathology
Female
Humans
Immunoenzyme Techniques
Keratins - analysis
Male
Membrane Proteins - analysis
Middle Aged
Mucin-1
Phosphopyruvate Hydratase - analysis
S100 Proteins - analysis
Online AccessGet more information

Cover

More Information
Summary:We present the cytologic features and the immunocytochemical profile of four cases of chordoma on fine-needle aspiration biopsies. The physaliferous cells in signet-ring, pearl-like formations and the trabecular arrangement with rounded contours are distinctive. Other cell types and cellular arrangements are also described. The negative immunoreactivity of carcinoembryonic antigen (CEA) and the positive staining pattern for neuron-specific enolase (NSE), S-100 protein, epithelial membrane antigen (EMA), and keratin provide a profile that, in the appropriate clinical setting, can be useful in the differential diagnosis of chordoma from similar-appearing neoplasms in small biopsies and fine-needle aspirates.
ISSN:8755-1039
DOI:10.1002/dc.2840020112