Synthesis and antiproliferative evaluation of novel triazolothiadiazine compounds

A novel series of triazolothiadiazines has been successfully synthesized with high efficiency through Knoevenagel condensation, utilizing thiocarbamoyl dihydrazine as the starting material. The structures of these compounds were characterized through 1H-NMR, 13C-NMR, high-resolution mass spectrometr...

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Bibliographic Details
Published inHeterocyclic Communications Vol. 31; no. 1; pp. 1895 - 905
Main Authors Lv Jiahui, Luo Xue, Du Yonghong, He Tiantian, Li Jinjing, Zhou Shujing
Format Journal Article
LanguageEnglish
Published Berlin Walter de Gruyter GmbH 01.08.2025
De Gruyter
Subjects
1,2,4-triazole
anti-proliferative activity
Antiproliferatives
Cancer
Condensates
Dihydrazine
knoevenagel condensation
Mass spectrometry
NMR
Nuclear magnetic resonance
Synthesis
thiadiazine
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Summary:A novel series of triazolothiadiazines has been successfully synthesized with high efficiency through Knoevenagel condensation, utilizing thiocarbamoyl dihydrazine as the starting material. The structures of these compounds were characterized through 1H-NMR, 13C-NMR, high-resolution mass spectrometry. The MTT assay was utilized to evaluate the in vitro cytotoxicity of the synthesized compounds against four human cancer cell lines including SW620, A549, Hela, and MCF-7. Among the tested compounds, (Z)-3-methyl-6-phenyl-7-(3-(trifluoromethyl)benzylidene)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine exhibited notably potent antiproliferative activity against all four human cancer cell lines.
Bibliography:ObjectType-Article-1
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ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2025-0181