Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near‐Infrared Spectral Region

• Published in: Angewandte Chemie Vol. 129; no. 11; pp. 3025 - 3029
• Main Authors: Lei, Zuhai, Li, Xinran, Luo, Xiao, He, Haihong, Zheng, Jing, Qian, Xuhong, Yang, Youjun
• Format: Journal Article
• Language: English; German
• Published: Weinheim Wiley Subscription Services, Inc 06.03.2017
• Subjects: Absorption; Aggregates; Bildgebung; Biocompatibility; Biomedical materials; Chemical compounds; Chemistry; Dyes; Fluorescence; Fluorescent dyes; Fluorescent indicators; Fluorophore; Fluorophores; I.R. radiation; Infrared spectra; Nahinfrarot; Near infrared radiation; Spectra; Spectral emittance
• ISSN: 0044-8249; 1521-3757
• DOI: 10.1002/ange.201612301

Small‐molecule organic fluorophores spectrally active in the 800–950 nm region are sought‐after for their broad potential in biomedical and material applications. We have developed a new family of brightly fluorescent dyes (ECX) to meet this challenge. ECX dyes are transparent to the visible region, while strongly absorbing in the NIR region at approximately 880 nm. They emit at around 915 nm with a fluorescence quantum yield up to 13.3 %. ECX dyes exhibit high chemostability, high photostability, and low tendency to aggregate. Other merits of ECX dyes include low degree of solvatochromism and facile post‐synthetic derivatization. ECX dyes potentially make available the 800–950 nm region for spectroscopic and microscopic applications and are also expected to find broad material applications. Helle und stabile niedermolekulare organische Fluorophore mit Absorption und Emission um 880 bzw. 915 nm eignen sich für die In‐vitro‐ und In‐vivo‐Bildgebung. Durch sie wird das rote Ende des biologischen NIR‐Spektralfensters für Mikroskopiestudien zugänglich. Außerdem kommen sie für materialtechnische Anwendungen in Betracht.