Reduction of Amides to Amines Catalyzed by Ca(CH2C6H4NMe2‐o)2(THF)2/HBpin

Reduction of amides to amines is an attractive subject in organic synthesis. Ca(CH2C6H4NMe2‐o)2(THF)2, an easily accessible main‐group complex, on combination with pinacolborane (HBpin) could serve as a highly active catalyst system in the reduction of primary, secondary and tertiary amides into the...

Full description

Saved in:
Bibliographic Details
Published inChemistrySelect (Weinheim) Vol. 8; no. 25
Main Authors Liu, Xunqingze, Xie, Hongzhen, Luo, Yunjie
Format Journal Article
LanguageEnglish
Published 07.07.2023
Subjects
Amide
Amine
Hydroboration
Organo calcium complex
Online AccessGet full text

Cover

More Information
Summary:Reduction of amides to amines is an attractive subject in organic synthesis. Ca(CH2C6H4NMe2‐o)2(THF)2, an easily accessible main‐group complex, on combination with pinacolborane (HBpin) could serve as a highly active catalyst system in the reduction of primary, secondary and tertiary amides into the corresponding amines. This protocol showed good tolerance for functional groups and heteroatoms, and the aimed products could be obtained in a gram‐scale. The active species in this transformation was supposed to be a calcium hydride. Ca(CH2C6H4NMe2‐o)2(THF)2/HBpin can serve as a highly active catalyst system for the reduction of primary, secondary and tertiary amides into amines.
ISSN:2365-6549
2365-6549
DOI:10.1002/slct.202301440