Synthesis of Phosphoryl-Substituted Benzimidazo[2,1-a]isoquinolin-6(5H)-ones from 2-Arylbenzoimidazoles and Diarylphosphine Oxides

An efficient and convenient silver-catalyzed procedure was developed for the synthesis of various phosphoryl-substituted benzimidazo[2,1-a]isoquinoline-6(5H)-ones from diarylphosphine oxides and 2-arylbenzoimidazoles. Moreover, the phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones could als...

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Bibliographic Details
Published inAsian journal of organic chemistry Vol. 8; no. 11; pp. 2042 - 2045
Main Authors Sun, Kai, Si, Ya-Feng, Chen, Xiao-Lan, Lv, Qi-Yan, Peng, Yu-Yu, Qu, Ling-Bo, Yu, Bing
Format Journal Article
LanguageEnglish
Published WEINHEIM Wiley 01.11.2019
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Phosphorylation
Silver-catalyzed
Benzimidazo
ANNULATION
STRATEGY
H-PHOSPHONATES
IONIC LIQUID
CATALYST
Radical Cyclization Reaction
ALCOHOLS
RADICAL CYCLIZATION
QUINOXALIN-2(1H)-ONES
BOND
1-a]isoquinolin-6(5H)-ones
EFFICIENT
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Summary:An efficient and convenient silver-catalyzed procedure was developed for the synthesis of various phosphoryl-substituted benzimidazo[2,1-a]isoquinoline-6(5H)-ones from diarylphosphine oxides and 2-arylbenzoimidazoles. Moreover, the phosphoryl-substituted indolo[2,1-a]isoquinolin-6(5H)-ones could also be achieved by using this strategy under mild reaction conditions in the presence of AgNO3/K2S2O8.
ISSN:2193-5807
2193-5815
DOI:10.1002/ajoc.201900570