3-(Het)arylglutamic acid hydrochlorides: synthesis and structure

Acid hydrolysis of 4-(het)aryl-3,5,5-tris(alkoxycarbonyl)-2-pyrrolidones obtained by the condensation of 1,1-bis(alkoxycarbonyl)ethenes with diethyl acetylaminomalonate leads to (2 R *,3 R *)-3-(het)arylglutamic acid hydrochlorides.

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Bibliographic Details
Published inRussian chemical bulletin Vol. 62; no. 11; pp. 2401 - 2406
Main Authors Berestovitskaya, V. M., Vasil’eva, O. S., Ostroglyadov, E. S., Tyurenkov, I. N., Anan’ev, I. V., Lyssenko, K. A., Perfilova, V. N., Bagmetova, V. V.
Format Journal Article
LanguageEnglish
Published Boston Springer US 01.11.2013
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Full Articles
Inorganic Chemistry
Organic Chemistry
glutamic acid
2-pyrrolidone
heterocyclization
diastereomers
Michael reaction
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Summary:Acid hydrolysis of 4-(het)aryl-3,5,5-tris(alkoxycarbonyl)-2-pyrrolidones obtained by the condensation of 1,1-bis(alkoxycarbonyl)ethenes with diethyl acetylaminomalonate leads to (2 R *,3 R *)-3-(het)arylglutamic acid hydrochlorides.
ISSN:1066-5285
1573-9171
DOI:10.1007/s11172-013-0348-y