Difference fluorescence spectroscopy of the structure and composition of bioactive preparations

A method for diagnosing the molecular structure and composition of aromatic bioactive preparations is developed by the example of pharmaceutical objects: analgin, citramon, aspirin, and paracetamol. The method is based on fiber-optic measurements of fluorescence spectra upon laser ultraviolet (266 n...

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Bibliographic Details
Published inBulletin of the Lebedev Physics Institute Vol. 38; no. 11; pp. 323 - 327
Main Authors Voinov, Yu. P., Gorelik, V. S., Umarov, M. F., Morozova, S. V.
Format Journal Article
LanguageEnglish
Published Heidelberg Allerton Press, Inc 01.11.2011
Subjects
Physics
Physics and Astronomy
pharmaceutical preparations
laser
fluorescence
biological objects
spectrum
ultraviolet light
correlation function
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Summary:A method for diagnosing the molecular structure and composition of aromatic bioactive preparations is developed by the example of pharmaceutical objects: analgin, citramon, aspirin, and paracetamol. The method is based on fiber-optic measurements of fluorescence spectra upon laser ultraviolet (266 nm) excitation with high (0.1 mm) spatial resolution. It is shown that the inhomogeneity of a pharmaceutical preparation containing several components is observed at a distance of a few millimeters. Difference fluorescence spectra are constructed, which allow detection of differences in preparation compositions and structures even in the case of closeness of their fluorescence spectra. The developedmethod can be used to control quality of a large class of bioactive structures luminescing under ultraviolet light.
ISSN:1068-3356
1934-838X
DOI:10.3103/S1068335611110029