Magnetic characteristics and anticancer activity of a nanocomplex consisting of detonation nanodiamond and doxorubicin

On the basis of detonation nanodiamond and doxorubicin antitumor drug a nanocomplex with magnetic properties of a soft ferromagnetic has been produced by mechano-magnetochemical synthesis. The combined action of the synthesized nanocomplex and local radio-frequency hyperthermia has been shown to ini...

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Bibliographic Details
Published inJournal of superhard materials Vol. 34; no. 3; pp. 179 - 185
Main Authors Orel, V. E., Shevchenko, A. D., Bogatyreva, G. P., Leshchenko, O. V., Romanov, A. V., Rykhal’s’kii, O. Yu, Dzyatkovskaya, I. I., Nikolov, N. A., Dzyatkovskaya, N. N., Shchepotin, I. B.
Format Journal Article
LanguageEnglish
Published Heidelberg Allerton Press, Inc 01.05.2012
Subjects
Chemistry
Chemistry and Materials Science
Physical Chemistry
Production
Properties
Structure
detonation nanodiamond
magnetic properties
doxorubicin
anticancer activity
mechano-magnetochemical synthesis
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Summary:On the basis of detonation nanodiamond and doxorubicin antitumor drug a nanocomplex with magnetic properties of a soft ferromagnetic has been produced by mechano-magnetochemical synthesis. The combined action of the synthesized nanocomplex and local radio-frequency hyperthermia has been shown to initiate the tendency for an increase of the growth inhibition of Walker-256 carcinosarcoma as compared to the monoeffects of the nanocomplex and officinal doxorubicin.
ISSN:1063-4576
1934-9408
DOI:10.3103/S1063457612030057