The microRNA-34 Family and Its Functional Role in Lung Cancer

Lung cancer is one of the most common malignant tumors in humans and the leading cause of cancer-related deaths worldwide. The microRNA-34 (miR-34) family is dysregulated in various human cancers and is an important family of tumor suppressor genes among microRNAs. The miR-34 family is downregulated...

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Published inAmerican journal of clinical oncology Vol. 47; no. 9; p. 448
Main Authors Zhang, Tinghua, Hu, Youyuan, Yang, Na, Yu, Shaofu, Pu, Xingxiang
Format Journal Article
LanguageEnglish
Published United States 01.09.2024
Subjects
Apoptosis
Cell Proliferation
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms - genetics
Lung Neoplasms - pathology
MicroRNAs - genetics
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Summary:Lung cancer is one of the most common malignant tumors in humans and the leading cause of cancer-related deaths worldwide. The microRNA-34 (miR-34) family is dysregulated in various human cancers and is an important family of tumor suppressor genes among microRNAs. The miR-34 family is downregulated in lung cancer. It inhibits cell proliferation, metastasis, and invasion, arrests the cell cycle, and induces apoptosis or senescence by negatively regulating many oncogenes. It is commonly used to detect and treat lung cancer. This study describes the regulatory role of the miR-34 family in lung cancer and the associated research advances in treatment.
ISSN:1537-453X
DOI:10.1097/COC.0000000000001106