Synthesis, structure, and pharmacological activity of (7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid

The synthesis of (7 R ,8 S )-epoxy-(13 R ,17 R )-trioxolane abietic acid was carried out and its structure was established by X-ray diffraction. The antineoplastic activity and the ability to induce apoptosis that were predicted by a PASS computer system, correlate well with the experimentally found...

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Published inRussian journal of bioorganic chemistry Vol. 39; no. 2; pp. 202 - 210
Main Authors Kazakova, O. B., Smirnova, I. E., Tkhu, H. Do Tkhi, Nguen, Tkhankh Tra, Apryshko, G. N., Zhukova, O. S., Medvedeva, N. I., Nazyrov, T. I., Tret’yakova, E. V., Chudov, I. V., Ismagilova, A. F., Suponitsky, K. Yu, Kazakov, D. V., Safarov, F. E., Tolstikov, G. A.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.03.2013
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Life Sciences
Organic Chemistry
ozonolysis
antiulcer activity
chemiluminescence
(7R,8S)-epoxy-(13R,17R)-trioxolane abietic acid
abietic acid
cytotoxicity
anti-inflammatory activity
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Summary:The synthesis of (7 R ,8 S )-epoxy-(13 R ,17 R )-trioxolane abietic acid was carried out and its structure was established by X-ray diffraction. The antineoplastic activity and the ability to induce apoptosis that were predicted by a PASS computer system, correlate well with the experimentally found cytotoxic activity towards the MeWo malignant cell line. The results of tests on animals showed that abietic acid and its (7 R ,8 S )-epoxy-(13 R ,17 R )-trioxolane derivative have anti-inflammatory and antiulcer activities in the absence of side effects.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162013020088