A simple and efficient synthesis of 2-aryl-substituted benzimidazoles

Sodium hydrogen sulfite was used to promote condensation of o -phenylenediamine with aromatic aldehydes in dimethylformamide to obtain the corresponding 2-arylbenzimidazoles. The procedure is simple and convenient, and it implies inexpensive promoter and is characterized by short reaction time and e...

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Bibliographic Details
Published inRussian journal of organic chemistry Vol. 44; no. 6; pp. 863 - 865
Main Authors Han, Xiangming, Ma, Huiqiang, Wang, Yulu
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.06.2008
Springer Nature
Subjects
Chemistry
Chemistry and Materials Science
Chemistry, Organic
Organic Chemistry
Physical Sciences
Science & Technology
Easy Purification
Azole
Aromatic Aldehyde
Sulfamic Acid
Benzimidazole
OXIDATION
PHASE SYNTHESIS
ACID
PROMOTED SYNTHESIS
BENZOXAZOLES
CONDENSATION
ALDEHYDES
O-PHENYLENEDIAMINE
CATALYST
DERIVATIVES
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Summary:Sodium hydrogen sulfite was used to promote condensation of o -phenylenediamine with aromatic aldehydes in dimethylformamide to obtain the corresponding 2-arylbenzimidazoles. The procedure is simple and convenient, and it implies inexpensive promoter and is characterized by short reaction time and easy purification of the final products.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428008060146