Regulation of FSH secretion: use of hydroxyurea to deplete germinal epithelium

Hydroxyurea, a chemotherapeutic agent that prevents mitosis by inhibiting DNA synthesis, was administered to adult male rats for 70 days. Plasma FSH and LH showed no systematic trend although severe germinal cell depletion was produced. These data suggest that the cell(s) of the seminiferous tubule...

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Bibliographic Details
Published inEndocrinology (Philadelphia) Vol. 96; no. 3; p. 564
Main Authors Mecklenburg, R S, Hetzel, W D, Gulyas, B J, Lipsett, M B
Format Journal Article
LanguageEnglish
Published United States 01.03.1975
Subjects
Animals
Follicle Stimulating Hormone - blood
Follicle Stimulating Hormone - secretion
Hydroxyurea - pharmacology
Luteinizing Hormone - blood
Male
Mitosis
Radioimmunoassay
Rats
Testis - cytology
Time Factors
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Summary:Hydroxyurea, a chemotherapeutic agent that prevents mitosis by inhibiting DNA synthesis, was administered to adult male rats for 70 days. Plasma FSH and LH showed no systematic trend although severe germinal cell depletion was produced. These data suggest that the cell(s) of the seminiferous tubule involved in FSH regulation must be either the type A spermatogonium or the Sertoli cell.
ISSN:0013-7227
DOI:10.1210/endo-96-3-564